Uncover generalized lipodystrophy in your practice

Generalized lipodystrophy is a rare, complex, and clinically heterogeneous disorder characterized by the widespread lack or loss of adipose tissue, leading to relative leptin deficiency and associated metabolic abnormalities.1

Leptin deficiency contributes to excess caloric intake, which exacerbates the metabolic abnormalities seen in patients with generalized lipodystrophy. Learn about the MYALEPT MOA

There are 2 types of generalized lipodystrophy

Congenital generalized lipodystrophy (CGL)

CGL Chart


A Lateral view of an 11-year-old boy with CGL showing generalized loss of fat, protuberant abdomen, prominent muscularity, and acromegaloid features such as large hands and feet.2


Acquired generalized lipodystrophy (AGL)

AGL Chart


B Lateral view of an 8-year-old boy with AGL. He started experiencing generalized loss of subcutaneous fat at age 3 with marked acanthosis nigricans in the neck, axillae, and groin. He developed Crohn’s disease at age 11, requiring hemicolectomy at age 13.4